A wide variety of pharmacological effects of Alprostadil are
vasodilation, inhibition of platelet aggregation, and stimulation
of intestinal and uterine smooth muscle. Alprostadil induces
erection by relaxation of trabecular smooth muscle and by dilation
of cavernosal arteries.
In vitro, Alprostadil has been shown to cause dose-dependent smooth
muscle relaxation in isolated corpus cavernosum and corpus
In human studies using Doppler duplex ultrasonography,
administration of Alprostadil resulted in an increase in peak
systolic flow velocities.
1. Cardiovascular disorders:
Maintaining the patency of the ductus arteriosus in neonates with
congenital heart disease until surgery is possible2.
2. Peripheral vascular disease:
Alprostadil can be administered by intra-arterial or intravenous
3. Erectile Dysfunction:
Intracavernous injection4, intra-urethral application5and non-invasive delivery systems including topical and needle-less
Befar, Caverject, Edex, Liple, Minprog, MUSE, Palus, Prostandin,
Prostavasin, ProstinVR, ProstineVR, Prostivas, Sutine, Topiglan®.
Alprostadil can be supplied as:
- Bulk Active Pharmaceutical Ingredient
- Alprostadil 100mcg/ml injection @ 5 x 1ml ampoules
Specs are available upon request